No one seems to have the answer to prevent sync center (mobsync.exe) from running on system startup on a Vista or Windows 7 machine. You check in msconfig, it’s not there, you check in your startup folder, not there.

If you’re not using the offline feature and wish to disable mobsync, Basil from reliancepc.com has created a free
tool to disable and reenable mobsync.exe. Thanks Basil. The tool basically amends permission on the.exe so it can not be launched.

Once disabled, you will need to log off and back on.

The tool created by Basil from reliancepc.com can be downloaded by clicking here. Run the exe to extract the files.

The download includes apps to disable and reenable mobsync.exe on Vista and Windows 7 machines. It also includes a script
which allows you to disable mobsync.exe only.

Another technique is to amend permissions on the mobsync.exe file manually so it’s unable to launch at system startup.

Two locations:

%windir%\sysnative\mobsync.exe

and/or

%windir%\system32\mobsync.exe

If you wish to prevent the application being used via group policy, click here.