If you receive the below error from Forefront Management Server, to resolve install the hotfix from http://support.microsoft.com/kb/940060/

Error:
The Management Server Service failed to import the updated antimalware definition.
Details
Result code: <error code>
Connection string:
Provider=SQLOLEDB.1;Integrated Security=SSPI;Persist Security Info=False;Initial Catalog=OnePoint;Data Source=Computer;Use Procedure for Prepare=1;Auto Translate=True;Packet Size=4096;Workstation ID=Computer;Use Encryption for Data=False;Tag with column collation when possible=False