If you wish to remove a selected number of local profiles via script but not all, for example remove all local profiles starting with 80 or 90 or pc etc, you can use the below script as a bat fileand run on system startup or shutdown via group policy.

Please note, deleting local profiles will also delete the my documents folder within the profile unless you have my documents folder redirection configured.

@echo off
c:
cd\documents and settings
for /f %%f IN (‘dir /b 10*; dir /b 11*; dir /b 12*;) DO rd /s /q %%f

Change the numbers 10, 11, 12 as required. The above script will delete local profiles starting with 10, 11 or 12.